Recommanded Product: 3-Methyl-1H-pyrrole. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 3-Methyl-1H-pyrrole, is researched, Molecular C5H7N, CAS is 616-43-3, about Direct Synthesis of Bipyrroles Using Phenyliodine Bis(trifluoroacetate) with Bromotrimethylsilane. Author is Dohi, Toshifumi; Morimoto, Koji; Maruyama, Akinobu; Kita, Yasuyuki.
Bipyrroles and a biindole are prepared regioselectively by oxidative dimerization of pyrroles or indoles with phenyliodine bis(trifluoroacetate) (PIFA) in the presence of bromotrimethylsilane. 3,4-Disubstituted pyrroles and 4,5,6,7-tetrahydroisoindole undergo dimerization to give 2,2′-bipyrroles (or 4,4′,5,5′,6,6′,7,7′-octahydro-1,1′-biisoindole) in 60-78% yields (with respect to PIFA). 3-Substituted-1H-pyrroles undergo regioselective oxidative dimerization with PIFA and bromotrimethylsilane to give 3,4′-disubstituted-2,2′-bipyrroles as the major products in 52-82% yields along with varying amounts of the 3,3′-disubstituted-2,2′-bipyrroles. 3-Methylindole undergoes oxidative dimerization to give 3,3′-dimethyl-2,2′-biindole in 74% yield in addition to 29% of 2-(3-methyl-1-indolyl)-3-methylindoline. While pyrrole undergoes oxidative dimerization with PIFA and bromotrimethylsilane to give only 2,2′-bipyrrole in 78% yield, 1-phenylpyrrole reacts under similar conditions to give 1,1′-diphenyl-2,3′-bipyrrole in 56% yield.
After consulting a lot of data, we found that this compound(616-43-3)Recommanded Product: 3-Methyl-1H-pyrrole can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate