The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: cis-4-Aminocyclohexane carboxylic acid(SMILESS: N[C@H]1CC[C@H](CC1)C(O)=O,cas:3685-23-2) is researched.Electric Literature of C5H7N. The article 《(R-X-R)4-motif peptides containing conformationally constrained cyclohexane-derived spacers: Effect on cellular uptake》 in relation to this compound, is published in ChemMedChem. Let’s take a look at the latest research on this compound (cas:3685-23-2).
Arg residue-rich peptides having the (R-X-R)n motif are among the most effective cell-penetrating peptides (CPPs). Here, we report a several-fold increase in the efficacy of such CPPs if the linear flexible spacer (-X-) in the (R-X-R) motif is replaced by constrained cyclic 1,4-substituted-cyclohexane-derived spacers. Internalization of these oligomers in mammalian cell lines was found to be an energy-dependent process. Incorporation of these constrained, non-proteinogenic amino acid spacers in the CPPs was shown to enhance their proteolytic stability.
This literature about this compound(3685-23-2)HPLC of Formula: 3685-23-2has given us a lot of inspiration, and I hope that the research on this compound(cis-4-Aminocyclohexane carboxylic acid) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate