Tag: M.W=100-200

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile( cas:56413-95-7 ) is researched.Synthetic Route of C6Cl2N4.Novakova, Veronika; Miletin, Miroslav; Filandrova, Tereza; Lenco, Juraj; Ruzicka, Ales; Zimcik, Petr published the article 《Role of Steric Hindrance in the Newman-Kwart Rearrangement and in the Synthesis and Photophysical Properties of Arylsulfanyl Tetrapyrazinoporphyrazines》 about this compound( cas:56413-95-7 ) in Journal of Organic Chemistry. Keywords: zinc phthalocyanine complex preparation fluorescence; crystal structure bisarylsulfanyl pyrazinedicarbonitrile. Let’s learn more about this compound (cas:56413-95-7).

Conditions for the Newman-Kwart rearrangement of phenols into thiophenols were studied in relation to the bulkiness of substituents at the 2 and 6 positions of the starting phenol derivative with an emphasis on eliminating side reactions. Thiophenols with different 2,6-disubstitution patterns (including hydrogen, Me, iso-Pr or tert-Bu groups) were used for the synthesis of 5,6-bis(arylsulfanyl)pyrazine-2,3-dicarbonitriles that underwent cyclotetramerization leading to the corresponding zinc tetrapyrazinoporphyrazines (TPyzPz), aza-analogs of phthalocyanines. Several methods for the cyclotetramerization were attempted to eliminate problematic side reactions. Magnesium butoxide is the most suitable cyclotetramerization agent and afforded TPyzPzs in reasonable yields of ∼30% under mild conditions. The varying arrangements of the peripheral substitutions resulting from the different bulkiness of the substituents were demonstrated by the x-ray structures of the pyrazine-2,3-dicarbonitriles. The prepared zinc arylsulfanyl TPyzPzs showed an absorption maximum at a Q-band over 650 nm, fluorescence quantum yields between 0.078 and 0.20, and singlet oxygen quantum yields ranging 0.58-0.69. TPyzPzs with iso-Pr groups are the best derivatives in this series as they combined facile cyclotetramerization, no aggregation, and good photophys. properties, which makes them potentially suitable for photodynamic therapy.

After consulting a lot of data, we found that this compound(56413-95-7)Synthetic Route of C6Cl2N4 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called cis-4-[[[(2-Chloroethyl)nitrosoamino]carbonyl]methylamino]cyclohexanecarboxylic acid, a nitrosourea with latent activity against an experimental solid tumor, published in 1984, which mentions a compound: 3685-23-2, mainly applied to cyclohexanecarboxylic acid nitrosoaminocarbonylamino; nitrosoaminocarbonylaminocyclohexanecarboxylate preparation antitumor; nitrosourea antitumor, HPLC of Formula: 3685-23-2.

The title compound (I) was synthesized in five steps from cis-4-aminocyclohexanecarboxylic acid via the N-tosylated intermediate II. I, which is incapable of the facile decomposition that characterizes the clin. useful nitrosoureas, effected a significant cure rate of both early and established murine Lewis lung carcinoma, even though its in vitro half-life was ∼5.5 times that of the unmethylated parent compound This is the first observation of latent activity of a nitrosourea against an exptl. solid tumor.

After consulting a lot of data, we found that this compound(3685-23-2)HPLC of Formula: 3685-23-2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Product Details of 56413-95-7. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile, is researched, Molecular C6Cl2N4, CAS is 56413-95-7, about Structural factors influencing the intramolecular charge transfer and photoinduced electron transfer in tetrapyrazinoporphyrazines.

Unsym. tetrapyrazinoporphyrazines (TPyzPzs) from the group of azaphthalocyanines with one peripherally attached amino substituent (donor) were synthesized, and their photophys. properties (fluorescence quantum yield and singlet oxygen quantum yield) were determined The synthesized TPyzPzs were expected to undergo intramol. charge transfer (ICT) as the main pathway for deactivating their excited states. Several structural factors play a critical role in ICT efficiency. The substituent in the ortho position to the donor center significantly influences the ICT, with tert-butylsulfanyl and butoxy substituents inducing the strongest ICTs, whereas chloro, Me, Ph, and hydrogen substituents in this position reduce the efficiency. The strength of the donor pos. influences the ICT efficiency and correlates well with the oxidation potential of the amines used as the substituents on the TPyzPz as follows: n-butylamine < N,N-diethylamine < aniline < phenothiazine. The ICT (with conjugated donors and acceptors) in the TPyzPz also proved to be much stronger than a photoinduced electron transfer in which the donor and the acceptor are connected through an aliphatic linker. After consulting a lot of data, we found that this compound(56413-95-7)Product Details of 56413-95-7 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Product Details of 3685-23-2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: cis-4-Aminocyclohexane carboxylic acid, is researched, Molecular C7H13NO2, CAS is 3685-23-2, about cis-4-[[[(2-Chloroethyl)nitrosoamino]carbonyl]methylamino]cyclohexanecarboxylic acid, a nitrosourea with latent activity against an experimental solid tumor. Author is Johnston, Thomas P.; McCaleb, George S.; Rose, William C.; Montgomery, John A..

The title compound (I) was synthesized in five steps from cis-4-aminocyclohexanecarboxylic acid via the N-tosylated intermediate II. I, which is incapable of the facile decomposition that characterizes the clin. useful nitrosoureas, effected a significant cure rate of both early and established murine Lewis lung carcinoma, even though its in vitro half-life was ∼5.5 times that of the unmethylated parent compound This is the first observation of latent activity of a nitrosourea against an exptl. solid tumor.

After consulting a lot of data, we found that this compound(3685-23-2)Product Details of 3685-23-2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Application of 56413-95-7. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile, is researched, Molecular C6Cl2N4, CAS is 56413-95-7, about Novel 5,7-disubstituted 6-amino-5H-pyrrolo[3,2-b]pyrazine-2,3-dicarbonitriles, the promising protein kinase inhibitors with antiproliferative activity. Author is Dubinina, G. G.; Platonov, M. O.; Golovach, S. M.; Borysko, P. O.; Tolmachov, A. O.; Volovenko, Y. M..

New derivatives of pyrrolo[2,3-b]pyrazine were synthesized and tested on a panel of cultured human tumor cell lines. It was found that 6-amino-5-(3-chlorophenylamino)-7-(1-methyl-1H-benzo[d]imidazol-2-yl)-5H-pyrrolo[3,2-b]pyrazine-2,3-dicarbonitrile (I) exhibited a significant antiproliferative activity: GI50 for cell lines RXF 393 (renal cancer) and BT-549 (breast cancer) were 14 and 82 nM, resp. To identify possible mol. targets, docking of the most active compounds into the active sites of cyclin-dependent kinases was performed. Mol. modeling of the inhibitor-enzyme complexes showed the differences in the binding poses of new pyrrolo[2,3-b]pyrazine derivatives in the kinase ATP-binding site compared with known pyrrolo[2,3-b]pyrazine inhibitors called aloisines. The patterns of drug kinase interactions correlated well with antiproliferative activities of novel derivatives Key interactions and binding mode of docked compounds are discussed.

After consulting a lot of data, we found that this compound(56413-95-7)Application of 56413-95-7 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Bures, Filip; Cermakova, Hana; Kulhanek, Jiri; Ludwig, Miroslav; Kuznik, Wojciech; Kityk, Iwan V.; Mikysek, Tomas; Ruzicka, Ales published an article about the compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile( cas:56413-95-7,SMILESS:N#CC1=NC(Cl)=C(Cl)N=C1C#N ).Product Details of 56413-95-7. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:56413-95-7) through the article.

Thirteen new, stable, push-pull systems featuring dimethylamino and pyrazine-2,3-dicarbonitrile moieties as the donor and acceptor, resp., and systematically extended and varied π-linkers were prepared and studied. Evaluation of the measured UV/Vis spectra, electrochem. data (cyclic voltammetry, rotating disk voltammetry, and polarog.), x-ray data, and exptl. determined and calculated hyperpolarizability values enabled structure-property studies; these revealed some important structural features that affected the efficiency of intramol. charge-transfer and nonlinear optical properties in this class of heterocyclic push-pull chromophores. The charge-transfer transition was most significantly affected by structural features such as π-linker length, chromophore planarity, and the number of 1,4-phenylene/ethynylene subunits in the π-linker.

After consulting a lot of data, we found that this compound(56413-95-7)Product Details of 56413-95-7 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Maksheeed, Saad; Ibrahim, Fadi; Samuel, Jacob; Helliwell, Madeleine; Warren, John E.; Bezzu, C. Grazia; McKeown, Neil B. published an article about the compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile( cas:56413-95-7,SMILESS:N#CC1=NC(Cl)=C(Cl)N=C1C#N ).Product Details of 56413-95-7. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:56413-95-7) through the article.

The synthesis of octaazaphthalocyanine (AzaPc) derivatives, with bulky phenoxyl substituents placed at eight peripheral positions and containing either H+, Ni2+ or Zn2+ ions in their central cavity, is described. The required precursors, derivatives of pyrazine-2,3-dicarbonitrile, were prepared using a nucleophilic aromatic substitution reaction between 2,6-diisopropylphenol or 2,6-diphenylphenol and 5,6-dichloropyrazine-2,3-dicarbonitrile. Anal. of the resulting AzaPcs by UV/Visible and 1H NMR spectroscopy confirms that steric isolation of the AzaPc cores was enforced both in solution and in the solid state. X-ray diffraction studies of single crystals of the AzaPcs reveal that solvent inclusion takes place in each case. Of particular significance is the finding that the Zn derivative of 2,3,9,10,16,17,23,24-octa-(2,6-diisopropylphenoxy)octaazaphthalocyanine provides nanoporous cubic crystals, containing massive (8 nm3) solvent-filled voids, similar to those of the analogous phthalocyanine derivative Exchange of the included solvent within the voids can be readily achieved by using a number of alternative solvents including H2O. Based on the observed loading of included H2O, the internal volume of this nanoporous cubic crystal appears to be more hydrophilic than its phthalocyanine counterpart.

After consulting a lot of data, we found that this compound(56413-95-7)Product Details of 56413-95-7 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Name: 5,6-Dichloropyrazine-2,3-dicarbonitrile. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile, is researched, Molecular C6Cl2N4, CAS is 56413-95-7, about A Multifunctional Reagent Designed for the Site-Selective Amination of Pyridines. Author is Fier, Patrick S.; Kim, Suhong; Cohen, Ryan D..

The development of a multifunctional reagent for the direct conversion of pyridines to Boc-protected 2-aminopyridines such as I [R = H, 3-Br, 4-Ph, etc.] with exquisite site selectivity and chemoselectivity was reported. The novel reagent was prepared on 200g scale in a single step, reacted in title reaction under mild conditions without precautions toward air or moisture, and is tolerant of nearly all common functionality. Exptl. and in situ spectroscopic monitoring techniques provided detailed insights and unexpected findings for the unique reaction mechanism.

After consulting a lot of data, we found that this compound(56413-95-7)Name: 5,6-Dichloropyrazine-2,3-dicarbonitrile can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile, is researched, Molecular C6Cl2N4, CAS is 56413-95-7, about Clathrate formation from octaazaphthalocyanines possessing bulky phenoxyl substituents: a new cubic crystal containing solvent-filled, nanoscale voids, the main research direction is octaazaphthalocyanine derivative ligand preparation nickel zinc complex; crystal structure octaazaphthalocyanine derivative ligand nickel zinc complex; clathrate formation zinc octaazaphthalocyanine derivative complex solvent.Application In Synthesis of 5,6-Dichloropyrazine-2,3-dicarbonitrile.

The synthesis of octaazaphthalocyanine (AzaPc) derivatives, with bulky phenoxyl substituents placed at eight peripheral positions and containing either H+, Ni2+ or Zn2+ ions in their central cavity, is described. The required precursors, derivatives of pyrazine-2,3-dicarbonitrile, were prepared using a nucleophilic aromatic substitution reaction between 2,6-diisopropylphenol or 2,6-diphenylphenol and 5,6-dichloropyrazine-2,3-dicarbonitrile. Anal. of the resulting AzaPcs by UV/Visible and 1H NMR spectroscopy confirms that steric isolation of the AzaPc cores was enforced both in solution and in the solid state. X-ray diffraction studies of single crystals of the AzaPcs reveal that solvent inclusion takes place in each case. Of particular significance is the finding that the Zn derivative of 2,3,9,10,16,17,23,24-octa-(2,6-diisopropylphenoxy)octaazaphthalocyanine provides nanoporous cubic crystals, containing massive (8 nm3) solvent-filled voids, similar to those of the analogous phthalocyanine derivative Exchange of the included solvent within the voids can be readily achieved by using a number of alternative solvents including H2O. Based on the observed loading of included H2O, the internal volume of this nanoporous cubic crystal appears to be more hydrophilic than its phthalocyanine counterpart.

After consulting a lot of data, we found that this compound(56413-95-7)Application In Synthesis of 5,6-Dichloropyrazine-2,3-dicarbonitrile can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Cunningham, Jo; Marshall, J.; Neal, M. J. published an article about the compound: cis-4-Aminocyclohexane carboxylic acid( cas:3685-23-2,SMILESS:N[C@H]1CC[C@H](CC1)C(O)=O ).Category: chiral-oxygen-ligands. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3685-23-2) through the article.

Uptake of aminocyclohexanecarboxylic acid (I) [39275-59-7] by frog retinas was temperature-sensitive and highly Na-dependent, and was inhibited by GABA [56-12-2], L-2,4-diaminobutyric acid (II) [1758-80-1], and β-alanine [107-95-9] with IC50 values of 0.32, 0.23, and 9.0 mM, resp. Radioautog. studies indicated that the sites of I-3H and GABA-3H uptake were identical, the compounds being accumulated almost exclusively in the horizontal cells. II-3H and β-alanine-3H were accumulated predominantly in the Mueller cells and photoreceptors, resp. Although II possesses affinity for the I (GABA) transport system in the horizontal cells, I and GABA apparently have no affinity for the (high affinity) II transport system in the Mueller cells.

Although many compounds look similar to this compound(3685-23-2)Category: chiral-oxygen-ligands, numerous studies have shown that this compound(SMILES:N[C@H]1CC[C@H](CC1)C(O)=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate