New research progress on 538-58-9 in 2021.The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. Quality Control of 1,5-Diphenylpenta-1,4-dien-3-one, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 538-58-9
We describe here the synthesis of dihydropyrimidines derivatives 3a-p, and evaluation of their alpha-glucosidase enzyme inhibition activities. Compounds 3b (IC50 = 62.4 ± 1.5 muM), 3c (IC50 = 25.3 ± 1.26 muM), 3d (IC50 = 12.4 ± 0.15 muM), 3e (IC50 = 22.9 ± 0.25 muM), 3g (IC50 = 23.8 ± 0.17 muM), 3h (IC50 = 163.3 ± 5.1 muM), 3i (IC50 = 30.6 ± 0.6 muM), 3m (IC50 = 26.4 ± 0.34 muM), and 3o (IC50 = 136.1 ± 6.63 muM) were found to be potent alpha-glucosidase inhibitors in comparison to the standard drug acarbose (IC50 = 840 ± 1.73 muM). The compounds were also evaluated for their in vitro cytotoxic activity against PC-3, HeLa, and MCF-3 cancer cell lines, and 3T3 mouse fibroblast cell line. All compounds were found to be non cytotoxic, except compounds 3f and 3m (IC50 = 17.79 ± 0.66-20.44 ± 0.30 muM), which showed a weak cytotoxic activity against the HeLa, and 3T3 cell lines. In molecular docking simulation study, all the compounds were docked into the active site of the predicted homology model of alpha-glucosidase enzyme. From the docking result, it was observed that most of the synthesized compounds showed interaction through carbonyl oxygen atom and polar phenyl ring with active site residues of the enzyme.
This is the end of this tutorial post, and I hope it has helped your research about 538-58-9 . Quality Control of 1,5-Diphenylpenta-1,4-dien-3-one
Reference：
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate