This type of reactivity has quickly become one of the cornerstones of modern catalysis .In a patent, Safety of 1,5-Diphenylpenta-1,4-dien-3-one, name is 1,5-Diphenylpenta-1,4-dien-3-one, belongs to chiral-oxygen-ligands compound, introducing its new discovery. Safety of 1,5-Diphenylpenta-1,4-dien-3-one
A new series, of gamma-amino butyric acid analogs were designed and synthesized as novel potent GABA-AT inhibitors. A structure-activity relationship study was performed by correlating the effect of different substituents with GABA-AT inhibitory activity of the title compounds. The preliminary bioassays showed that acid hydrazones exhibited excellent inhibitory activities in micromolar (0.07-0.56 muM) range, while Schiff’s bases showed variable results. The most potent compound, 4-amino-N’-[(1Z)-1-(2-bromophenyl) ethylidene]butanehydrazide (AHG177) showed inhibitory potency (IC50) of 0.073 muM. Aminobutyrate transaminase is a pyridoxal-P enzyme which follows a bi-bi ping pong mechanism and in pyridoxamine form can readily transaminate only with succinic semialdehyde and 2-oxoglutarate. The results strongly suggest that only the pyridoxal form of the enzyme is capable of reacting with the ligands. Our findings open up the possibility to extend this protocol to different databases in order to find new potential inhibitor for promising targets based on a rational drug design process.
However, they have proven to be challenging because of the mutual inactivation of both catalysts. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 538-58-9
Reference：
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate