Category: chiral-oxygen-ligands. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: cis-4-Aminocyclohexane carboxylic acid, is researched, Molecular C7H13NO2, CAS is 3685-23-2, about cis-4-[[[(2-Chloroethyl)nitrosoamino]carbonyl]methylamino]cyclohexanecarboxylic acid, a nitrosourea with latent activity against an experimental solid tumor. Author is Johnston, Thomas P.; McCaleb, George S.; Rose, William C.; Montgomery, John A..
The title compound (I) was synthesized in five steps from cis-4-aminocyclohexanecarboxylic acid via the N-tosylated intermediate II. I, which is incapable of the facile decomposition that characterizes the clin. useful nitrosoureas, effected a significant cure rate of both early and established murine Lewis lung carcinoma, even though its in vitro half-life was ∼5.5 times that of the unmethylated parent compound This is the first observation of latent activity of a nitrosourea against an exptl. solid tumor.
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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate