Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Methyl-1H-pyrrole, is researched, Molecular C5H7N, CAS is 616-43-3, about Delayed exchange of hydrogen in imine groups of pyrrole and indole.Name: 3-Methyl-1H-pyrrole.
The rate of H-D exchange between EtOD and pyrrole (I) or indole (II) in CCl4 was measured by NMR, and the rate constants were calculated from the 1st-order rate equation. The H exchange in NH groups of unsubstituted 5 membered heterocycles in the absence of an electron-donating solvent was slow. The photoionization potentials, Ip, of I, N-methylpyrrole (III), α-methylpyrrole (IV), and β-methylpyrrole were measured. The highest and the smallest Ip change was observed on passing from I to IV, and from I to III, resp. The probable structures of I complexes and I complexes with the alc. were suggested together with the causes of slow H exchange.
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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate