In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Elucidation of the mechanism of pyrrole formation during thermal degradation of 13C-labeled L-serines, published in 2001-07-31, which mentions a compound: 616-43-3, mainly applied to serine Maillard reaction pyrrole pyrazine, Recommanded Product: 616-43-3.
Pyrolysis of [13C-1], [13C-2] and [13C-3]-labeled L-serines generated mono-substituted Me and Et derivatives of pyrroles and pyrazines among other compounds Analyses of label incorporation into the pyrroles have indicated their formation through aldol condensation of acetaldehyde with different α-aminocarbonyl compounds followed by cyclization and loss of water (Knorr pyrrole synthesis). Comparison of the label incorporation patterns of the α-aminocarbonyls involved in the formation of Me and ethyl-substituted pyrroles with that of similarly substituted pyrazines, revealed their common origin. In addition, α-aminocarbonyls involved in the formation of 2- and 3-substituted pyrroles had identical label distribution patterns, indicating their formation through the same carbonyl precursors. Furthermore, the major pathway (55%) leading to the formation of the α-aminocarbonyl precursors of methyl-substituted pyrroles involved aldol addition of formaldehyde to glycolaldehyde, whereas the only pathway leading to the formation of the α-aminocarbonyl precursors of ethyl-substituted pyrroles involved the interaction of alanine – formed in situ – with glycolaldehyde.
Compound(616-43-3)Recommanded Product: 616-43-3 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(3-Methyl-1H-pyrrole), if you are interested, you can check out my other related articles.
Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate