4254-15-3, The molecularity of an elementary reaction is the number of molecules that collide during that step in the mechanism. If there is only a single reactant molecule in an elementary reaction, that step is designated as unimolecular.4254-15-3, name is (S)-Propane-1,2-diol. A new synthetic method of this compound is introduced below.
To (S)-propane diol (4.89 g, 64.2 mmol) in DCM (20 ml_) at -20 0C (CO2/ ethylene glycol bath) was added TEA (11.2 ml_, 80.3 mmol) followed by p-toluenesulfonyl chloride (12.3 g, 64.3 mmol) in DCM (26 mL) dropwise over 30 minutes. The cold bath was allowed to expire while stirring for 26h. DCM was added and the reaction was washed with 1 N HCI, water, and brine. The organic layer was dried (MgSO4), filtered, and concentrated in vacuo. The residue was purified by silica gel chromatography (0-40% EtOAc/Hex over 40 minutes) to provide the tosylate (8.37 g, 36 .4 mmol).
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Reference£º
Patent; SCHERING CORPORATION; WO2009/5645; (2009); A1;,
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