The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: cis-4-Aminocyclohexane carboxylic acid( cas:3685-23-2 ) is researched.Synthetic Route of C7H13NO2.Litvin, E. F.; Freidlin, L. Kh.; Oparina, G. K.; Gurskii, R. N.; Istratova, R. V.; Gosteva, L. I. published the article 《Hydrogenation of 4-aminobenzoic acid on catalysts of the platinum group》 about this compound( cas:3685-23-2 ) in Zhurnal Organicheskoi Khimii. Keywords: kinetics hydrogenation aminobenzoic acid; benzoic acid amino hydrogenation; catalyst hydrogenation aminobenzoic acid. Let’s learn more about this compound (cas:3685-23-2).
The rate of 4-H2NC6H4-CO2H hydrogenation to cis-4-aminocyclohexanecarboxylic acid and isomerization of the latter to the trans acid at 90-170° and 80 atm increased in the order of catalysts Pd ∼ Pt < Ru ≪ Rh and was higher with metal on C than with metal black; these reaction rates decreased in the order of solvents H2O > dioxane > EtOH > Me2SO > cyclohexylamine, and with Ru/C and Rh/C, decreased in the order of mineral acids H2SO4 > H3PO4 > HCl. At 90° the product stereochem. was determined by the reduction mechanism, and not by the rate of the secondary isomerization; the cis-trans ratio decreased in the order Ru > Rh > Pt > Pd.
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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate