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Antimicrobial Activity of Monoketone Curcuminoids Against Cariogenic Bacteria
We evaluated the antimicrobial activity of 25 monoketone curcuminoids (MKCs) against a representative panel of cariogenic bacteria in terms of their minimum inhibitory concentration (MIC) values. Curcumin A (10) displayed promising activity against Streptococcus mutans (MIC?=?50?mug/ml) and Streptococcus mitis (MIC?=?50?mug/ml) as well as moderate activity against S.?sanguinis (MIC?=?100?mug/ml), Lactobacillus casei (MIC?=?100?mug/ml), and Streptococcus salivarius (MIC?=?200?mug/ml). Results indicated higher activity of compound 10 than that of its bis-beta-diketone analog. Additionally, compounds 3a (1,5-bis(4-methylphenyl)pentan-3-one) and 7b (1,5-bis(4-bromophenyl)pentan-3-ol) were moderately active against S.?mitis (MIC?=?100?mug/ml) and S.?salivarus (MIC?=?200?mug/ml).
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Reference£º
Synthesis and Crystal Structure of a Chiral?C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur¨Cnitrogen¨Coxygen ligand derived from aminothiourea and sodium?D-camphor-¦Â-sulfonate