The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. An article , which mentions SDS of cas: 19132-06-0, molecular formula is C4H10O2. The compound – (2S,3S)-Butane-2,3-diol played an important role in people’s production and life., SDS of cas: 19132-06-0
Regio-, Diastereo-, and Enantioselective Synthesis of vic-Diols via alpha-Silyl Ketones According to the SAMP/RAMP Hydrazone Method
alpha-Silylated ketones 5 or 10 of high enantiomeric purity (ee>=90percent) are easily available by silylation or silylation/alkylation of ketones 1 or 6, resp., according to the SAMP/RAMP hydrazone method.Reduction of 5 or 10 with L-selectride<*>, followed by oxidative cleavage of the C-Si bond, leads to vic-diols 11-13 with high diastereoselectivity (de>=90percent) and without racemization.The stereoselectivity of the reduction depends on the structure of the alpha-silyl ketones 5 or 10, the reducing reagents, and the solvents used.Key Words: Ketones, alpha-silyl / vic-Diols, diastereo- and enantioselective synthesis / SAMP/RAMP Hydrazones / L-Selectride reductions
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Reference£º
Synthesis and Crystal Structure of a Chiral?C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur¨Cnitrogen¨Coxygen ligand derived from aminothiourea and sodium?D-camphor-¦Â-sulfonate