Safety of 5,6-Dichloropyrazine-2,3-dicarbonitrile. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5,6-Dichloropyrazine-2,3-dicarbonitrile, is researched, Molecular C6Cl2N4, CAS is 56413-95-7, about Synthesis of mono-, di-, tri- and tetracarboxy azaphthalocyanines as potential dark quenchers. Author is Kopecky, Kamil; Satinsky, Dalibor; Novakova, Veronika; Miletin, Miroslav; Svoboda, Antonin; Zimcik, Petr.
Mono-, di-, tri- and tetracarboxy-substituted metal-free azaphthalocyanines (AzaPc) were synthesized from 5,6-bis(diethylamino)pyrazine-2,3-dicarbonitrile and 6-(5,6-dicyano-3-(diethylamino)pyrazin-2-ylamino)hexanoic acid using a statistical condensation approach. AzaPc bearing eight diethylamino peripheral substituents was also isolated from the mixture Anal. of the distribution of congeners in the statistical mixture using optimized HPLC method (Phenomenex Synergy RP Fusion column, acetonitrile/tetrahydrofuran/water (pH 5.5) 50:20:30) was performed. The anal. showed optimal ratios of starting materials to be 3:1 for AAAB, 1:3 for ABBB and 1:1 for AABB/ABAB types of the congeners. The distribution of the congeners corresponded well with calculated values indicating similar reactivity of both starting materials and no steric constraint between adjacent isoindole units in the AzaPc ring. All studied AzaPc showed no fluorescence, extremely low singlet oxygen quantum yields (Φ Δ < 0.005) in monomeric form and strong absorption in a wide range from 300 nm to almost 700 nm. Such properties are highly promising for future study of these compounds as dark quenchers of fluorescence in DNA hybridization probes. If you want to learn more about this compound(5,6-Dichloropyrazine-2,3-dicarbonitrile)Safety of 5,6-Dichloropyrazine-2,3-dicarbonitrile, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(56413-95-7).
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