The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: cis-4-Aminocyclohexane carboxylic acid( cas:3685-23-2 ) is researched.Formula: C7H13NO2.Palaima, A.; Staniulyte, Z.; Juodvirsis, A. published the article 《Proton NMR spectroscopic study of the stereoconfiguration and conformation of cis and trans isomers of 3- and 4-aminocyclohexylalkanoic acids》 about this compound( cas:3685-23-2 ) in Chemija. Keywords: aminocyclohexanealkanoic acid conformation configuration NMR; cyclohexanealkanoic acid amino conformation configuration NMR. Let’s learn more about this compound (cas:3685-23-2).
1H NMR spectral data for cyclohexane H1, H3 or H1, H4 protons of cis- and trans-3- and 4-aminocyclohexanealkanoic acids were successfully used for determination of the stereoconfigurations and conformational equilibrium of sep. isomers and for determination of cis/trans ratio in their mixtures by using Pr(NO3)3 and Eu(fod)3 as shift-reagents. For that purpose NMR data of the alkanoic substituents of the cyclohexane ring can also be used.
After consulting a lot of data, we found that this compound(3685-23-2)Formula: C7H13NO2 can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate