So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Ding, Yun; Belyanskaya, Svetlana; DeLorey, Jennifer L.; Messer, Jeffrey A.; Joseph Franklin, G.; Centrella, Paolo A.; Morgan, Barry A.; Clark, Matthew A.; Skinner, Steven R.; Dodson, Jason W.; Li, Peng; Marino, Joseph P. Jr.; Israel, David I. researched the compound: cis-4-Aminocyclohexane carboxylic acid( cas:3685-23-2 ).Synthetic Route of C7H13NO2.They published the article 《Discovery of soluble epoxide hydrolase inhibitors through DNA-encoded library technology (ELT)》 about this compound( cas:3685-23-2 ) in Bioorganic & Medicinal Chemistry. Keywords: soluble epoxide hydrolase inhibitor GSK2256294 DNA encoded library; DNA-encoded library technology; Soluble epoxide hydrolase. We’ll tell you more about this compound (cas:3685-23-2).
Inhibition of soluble epoxide hydrolase (sEH) has recently emerged as a new approach to treat cardiovascular disease and respiratory disease. Inhibitors based on 1,3,5-triazine chemotype were discovered through affinity selection against two triazine-based DNA-encoded libraries. The structure and activity relationship study led to the expansion of the original 1,4-cycloalkyl series to related aniline, piperidine, quinoline, aryl-ether and benzylic series. The 1,3-cycloalkyl chemotype led to the discovery of a clin. candidate (GSK2256294, I) for COPD.
This literature about this compound(3685-23-2)Synthetic Route of C7H13NO2has given us a lot of inspiration, and I hope that the research on this compound(cis-4-Aminocyclohexane carboxylic acid) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate