Category: 3685-23-2

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Renin inhibitory pentols showing improved enteral bioavailability, published in 1992-02-07, which mentions a compound: 3685-23-2, Name is cis-4-Aminocyclohexane carboxylic acid, Molecular C7H13NO2, Application of 3685-23-2.

Aminopentols derived from L-(+)-glucose and D-(+)-mannose were prepared and tested for renin-inhibiting activity as well as bioavailability. Incorporation of a C-terminal pentahydroxy functionality led to potent, low mol. weight hydrophilic renin inhibitors lacking the p1′ side chain. I was transported across rabbit intestinal brush border membrane vesicles and yielded a hypotensive effect in sodium-depleted rhesus monkeys which lasted for 90 min when dosed at 2 mg/kg, intraduodenally.

The article 《Renin inhibitory pentols showing improved enteral bioavailability》 also mentions many details about this compound(3685-23-2)Application of 3685-23-2, you can pay attention to it, because details determine success or failure

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: cis-4-Aminocyclohexane carboxylic acid( cas:3685-23-2 ) is researched.Formula: C7H13NO2.Palaima, A.; Staniulyte, Z.; Juodvirsis, A. published the article 《Proton NMR spectroscopic study of the stereoconfiguration and conformation of cis and trans isomers of 3- and 4-aminocyclohexylalkanoic acids》 about this compound( cas:3685-23-2 ) in Chemija. Keywords: aminocyclohexanealkanoic acid conformation configuration NMR; cyclohexanealkanoic acid amino conformation configuration NMR. Let’s learn more about this compound (cas:3685-23-2).

1H NMR spectral data for cyclohexane H1, H3 or H1, H4 protons of cis- and trans-3- and 4-aminocyclohexanealkanoic acids were successfully used for determination of the stereoconfigurations and conformational equilibrium of sep. isomers and for determination of cis/trans ratio in their mixtures by using Pr(NO3)3 and Eu(fod)3 as shift-reagents. For that purpose NMR data of the alkanoic substituents of the cyclohexane ring can also be used.

After consulting a lot of data, we found that this compound(3685-23-2)Formula: C7H13NO2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Quality Control of cis-4-Aminocyclohexane carboxylic acid. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-4-Aminocyclohexane carboxylic acid, is researched, Molecular C7H13NO2, CAS is 3685-23-2, about Synthesis of peptidelike derivatives of cis- and trans-4-aminocyclohexanecarboxylic acids containing sarcolysin residues. Author is Karpavicius, K.; Patockiene, L.; Knunyants, I. L..

Mixed-anhydride and dicyclohexylcarbodiimide coupling reactions of N-formysarcolysin and N-(benzyloxycarbonyl)sarcolysin with cis- and trans-4-aminocyclohexanecarboxylic acid esters and subsequent deblocking gave the cis- and trans- sarcolysylaminocyclohexanecarboxylates I (R = H, Et). Condensation of sarcolysin benzyl ester with cis- and trans-4-(benzyloxycarbonylamino)cyclohexancarboxylate and subsequent deblocking gave the cis- and trans-N-(cyclohexylcarbonyl)sarcolysins II.

After consulting a lot of data, we found that this compound(3685-23-2)Quality Control of cis-4-Aminocyclohexane carboxylic acid can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Alen, Jo; De Borggraeve, Wim M.; Compernolle, Frans; Hoornaert, Georges J. published the article 《Evaluation of the β-turn-inducing properties of an analog of (amino)piperidinonecarboxylates》. Keywords: beta turn mimetic acetylamino cyclohexanecarboxamide preparation.They researched the compound: cis-4-Aminocyclohexane carboxylic acid( cas:3685-23-2 ).Recommanded Product: 3685-23-2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:3685-23-2) here.

Cis-4-(Acetylamino)-N-(methyl)cyclohexanecarboxamide has been selected as all carbon ring analog of previously described 5-(amino)piperidinone-2-carboxylate systems. The potential β-turn-inducing properties of this model compound are evaluated by means of NMR anal. and mol. modeling. It was found that suitable as β-turn-inducing scaffold. Apparently, the planar lactam function in the native (amino)(oxo)piperidinecarboxylate systems is important to impose a correct conformation for β-turn induction.

After consulting a lot of data, we found that this compound(3685-23-2)Recommanded Product: 3685-23-2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) called Synthesis of peptides containing cis- or trans-3- or 4-aminocyclohexanecarboxylic acid residues, Author is Skaric, Vinko; Kovacevic, Mice; Skaric, Djurdja, which mentions a compound: 3685-23-2, SMILESS is N[C@H]1CC[C@H](CC1)C(O)=O, Molecular C7H13NO2, Application of 3685-23-2.

Et tert-butoxycarbonylphenylalanyl-trans- and -cis-4-aminocyclohexanecarboxylates were prepared by coupling the N-hydroxysuccinimido ester of tert-butoxycarbonylphenylalanine with a mixture of isomers of Et 4-aminocyclohexanecarboxylate. Treatment of the hydroxysuccinimido esters of tert-butoxycarbonylphenylalanyl-trans-4- and -cis-3-aminocyclohexanecarboxylic acids with S-benzylcysteine Me ester gave tert-butoxycarbonylphenylalanyl-trans-4- and -cis-3-aminocyclohexylcarbonyl-S-benzylcysteine Me ester.

The article 《Synthesis of peptides containing cis- or trans-3- or 4-aminocyclohexanecarboxylic acid residues》 also mentions many details about this compound(3685-23-2)Application of 3685-23-2, you can pay attention to it, because details determine success or failure

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis of an octadecapeptide and its 18-amide analog corresponding to the first eighteen amino acid residues of corticotropin (ACTH) and their biological activities》. Authors are Otsuka, Hideo; Inouye, Ken; Shinozaki, Fusako; Kanayama, Makoto.The article about the compound:cis-4-Aminocyclohexane carboxylic acidcas:3685-23-2,SMILESS:N[C@H]1CC[C@H](CC1)C(O)=O).Recommanded Product: 3685-23-2. Through the article, more information about this compound (cas:3685-23-2) is conveyed.

The title compound (I) and its 18-amide analog (II) were synthesized. The activities of I, II, H-Gly-Tyr-Ser-Met-Glu-His-Phe-Arg-Try-Gly-Lys-Pro-Val-Gly-Arg-Arg-OH (III) (CA 63, 670f), and H-Gly-Tyr-Ser-Met-Glu-His-Phe-Arg-Try-Gly-Lys-Pro-Val-Gly-Lys-Arg-Arg-NH2 (IV) (CA 63, 16462d) were compared (cf. the table). (BOC = tert-BuO2C and Cbz = PhCH2O2C). Steroidogenic U.S.P. units/mg., Lipolytic minimal effective dose (γ); In vivo, In vitro, Rabbit, Rat; I, 17.07, 9.35, 0.000075, 0.0045; II, 39.6;58.0, 4.7;11.5, 0.000004, 0.0027; III, 0.124, 0.134, 0.00093, 0.021; IV, 2.72; 1.26, 0.00042, 0.0037; Coupling of BOC-Ser-Tyr-Ser-Met-N3 with H-Glu(γ-tert-Bu)-His-Phe-Arg-Try-Gly-OH gave BOC-Ser-Tyr-Ser-Met-Glu(γ-tert-Bu)-His-Phe-Arg-Try-Gly-OH (V), m. 202° (decomposition), [α]24D -13.2° (c 1.0, HCONMe2). Reaction of Cbz-Lys(BOC)-Pro-Val-Gly-Lys(BOC)-N3 with either H-Lys(BOC)-Arg-Arg-OH or its amide gave Cbz-Lys(BOC)-Pro-Val-Gly-Lys(BOC)-Lys(BOC)-Arg-Arg-OH (VI), [α]25.5D -46.1° (c 1.0, 50% AcOH), or its amide (VII), [α]22.5D -43.7° (c 1.75, 50% AcOH). Coupling of N-hydroxysuccinimide ester of V with the hydrogenolyzed VI or VII gave BOC-Ser-Tyr-Ser-Met-Glu(γ-tert-Bu)-His-Phe-Arg-Try-Gly-Lys(BOC)-Pro-Val-Gly-Lys(BOC)-Lys(BOC)-Arg-Arg-OH (VIII) or its amide (IX), resp. VIII was purified on carboxymethyl cellulose columns and treated with 90% F3CCO2H to give I, λ (0.1N NaOH) 281.5 mμ (ε 7030), 288.5 mμ (ε 6820), [α]25D -54.6° (c 0.5, 0.1N AcOH). Similarly, IX gave II, λ (0.1N NaOH) 281.5 mμ (ε 7050), 288.5 mμ (ε 6740), [α]24D -55.8° (c 0.5, 0.1N AcOH). Amino acid analysis of I and II confirmed their structures.

The article 《Synthesis of an octadecapeptide and its 18-amide analog corresponding to the first eighteen amino acid residues of corticotropin (ACTH) and their biological activities》 also mentions many details about this compound(3685-23-2)Recommanded Product: 3685-23-2, you can pay attention to it, because details determine success or failure

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: cis-4-Aminocyclohexane carboxylic acid, is researched, Molecular C7H13NO2, CAS is 3685-23-2, about Synthesis of derivatives of stereoisomeric aminocyclohexanecarboxylic acids containing an acyl residue of p-[bis(2-chloroethyl)amino]phenylacetic acid, the main research direction is chloroethylamino phenylacetamide carboxycyclohexyl; aminophenyl acetamide chloroethyl carboxycyclohexyl; cyclohexyl bischloroethylaminophenylacetamide.Recommanded Product: cis-4-Aminocyclohexane carboxylic acid.

Cyclohexylamines I (R = cis- and trans-4-CO2H and -CH2CO2H, H, cis-3-CO2H) reacted with 4-(ClCH2CH2)2NC6H4CH2COCl to give amides II in 55-72% yield. I (R = trans-4-CO2Et) reacted with 4-(ClCH2CH2)2NC6H4CH2CO2H in presence of dicyclohexylcarbodiimide or ClCO2Bu to give resp. II.

The article 《Synthesis of derivatives of stereoisomeric aminocyclohexanecarboxylic acids containing an acyl residue of p-[bis(2-chloroethyl)amino]phenylacetic acid》 also mentions many details about this compound(3685-23-2)Recommanded Product: cis-4-Aminocyclohexane carboxylic acid, you can pay attention to it, because details determine success or failure

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

Electric Literature of C7H13NO2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: cis-4-Aminocyclohexane carboxylic acid, is researched, Molecular C7H13NO2, CAS is 3685-23-2, about Synthesis of peptides containing cis- or trans-3- or 4-aminocyclohexanecarboxylic acid residues.

Et tert-butoxycarbonylphenylalanyl-trans- and -cis-4-aminocyclohexanecarboxylates were prepared by coupling the N-hydroxysuccinimido ester of tert-butoxycarbonylphenylalanine with a mixture of isomers of Et 4-aminocyclohexanecarboxylate. Treatment of the hydroxysuccinimido esters of tert-butoxycarbonylphenylalanyl-trans-4- and -cis-3-aminocyclohexanecarboxylic acids with S-benzylcysteine Me ester gave tert-butoxycarbonylphenylalanyl-trans-4- and -cis-3-aminocyclohexylcarbonyl-S-benzylcysteine Me ester.

The article 《Synthesis of peptides containing cis- or trans-3- or 4-aminocyclohexanecarboxylic acid residues》 also mentions many details about this compound(3685-23-2)Electric Literature of C7H13NO2, you can pay attention to it, because details determine success or failure

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: cis-4-Aminocyclohexane carboxylic acid(SMILESS: N[C@H]1CC[C@H](CC1)C(O)=O,cas:3685-23-2) is researched.HPLC of Formula: 56413-95-7. The article 《Synthesis and properties of 2-azabicyclo[2:2:2]octan-3-one and 6-azabicyclo[3:2:1]octan-7-one》 in relation to this compound, is published in Rigas Tehniskas Universitates Zinatniskie Raksti, Serija 1: Materialzinatne un Lietiska Kimija. Let’s take a look at the latest research on this compound (cas:3685-23-2).

Optimal reaction conditions for the synthesis of lactams of cis-3- and -4-ACH acids and their derivatives were determined 1H NMR spectral data confirmed different configuration of lactams of cis-3- and cis-4-derivatives Possibility to apply lactams for the separation of cis- and trans-isomers was investigated.

After consulting a lot of data, we found that this compound(3685-23-2)Application In Synthesis of cis-4-Aminocyclohexane carboxylic acid can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called cis-4-[[[(2-Chloroethyl)nitrosoamino]carbonyl]methylamino]cyclohexanecarboxylic acid, a nitrosourea with latent activity against an experimental solid tumor, published in 1984, which mentions a compound: 3685-23-2, mainly applied to cyclohexanecarboxylic acid nitrosoaminocarbonylamino; nitrosoaminocarbonylaminocyclohexanecarboxylate preparation antitumor; nitrosourea antitumor, HPLC of Formula: 3685-23-2.

The title compound (I) was synthesized in five steps from cis-4-aminocyclohexanecarboxylic acid via the N-tosylated intermediate II. I, which is incapable of the facile decomposition that characterizes the clin. useful nitrosoureas, effected a significant cure rate of both early and established murine Lewis lung carcinoma, even though its in vitro half-life was ∼5.5 times that of the unmethylated parent compound This is the first observation of latent activity of a nitrosourea against an exptl. solid tumor.

After consulting a lot of data, we found that this compound(3685-23-2)HPLC of Formula: 3685-23-2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate