The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. An article , which mentions Safety of 1,5-Diphenylpenta-1,4-dien-3-one, molecular formula is C17H14O. The compound – 1,5-Diphenylpenta-1,4-dien-3-one played an important role in people’s production and life., Safety of 1,5-Diphenylpenta-1,4-dien-3-one
We describe here the synthesis of dihydropyrimidines derivatives 3a-p, and evaluation of their alpha-glucosidase enzyme inhibition activities. Compounds 3b (IC50 = 62.4 ± 1.5 muM), 3c (IC50 = 25.3 ± 1.26 muM), 3d (IC50 = 12.4 ± 0.15 muM), 3e (IC50 = 22.9 ± 0.25 muM), 3g (IC50 = 23.8 ± 0.17 muM), 3h (IC50 = 163.3 ± 5.1 muM), 3i (IC50 = 30.6 ± 0.6 muM), 3m (IC50 = 26.4 ± 0.34 muM), and 3o (IC50 = 136.1 ± 6.63 muM) were found to be potent alpha-glucosidase inhibitors in comparison to the standard drug acarbose (IC50 = 840 ± 1.73 muM). The compounds were also evaluated for their in vitro cytotoxic activity against PC-3, HeLa, and MCF-3 cancer cell lines, and 3T3 mouse fibroblast cell line. All compounds were found to be non cytotoxic, except compounds 3f and 3m (IC50 = 17.79 ± 0.66-20.44 ± 0.30 muM), which showed a weak cytotoxic activity against the HeLa, and 3T3 cell lines. In molecular docking simulation study, all the compounds were docked into the active site of the predicted homology model of alpha-glucosidase enzyme. From the docking result, it was observed that most of the synthesized compounds showed interaction through carbonyl oxygen atom and polar phenyl ring with active site residues of the enzyme.
However, they have proven to be challenging because of the mutual inactivation of both catalysts. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 538-58-9
Reference：
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate