Awesome and Easy Science Experiments about 3685-23-2

The article 《(R-X-R)4-motif peptides containing conformationally constrained cyclohexane-derived spacers: Effect on cellular uptake》 also mentions many details about this compound(3685-23-2)COA of Formula: C7H13NO2, you can pay attention to it, because details determine success or failure

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3685-23-2, is researched, Molecular C7H13NO2, about (R-X-R)4-motif peptides containing conformationally constrained cyclohexane-derived spacers: Effect on cellular uptake, the main research direction is cell penetrating peptide derivative preparation role cellular uptake; (R-X-R)-motif; cell-penetrating peptides; cellular uptake; protease stability.COA of Formula: C7H13NO2.

Arg residue-rich peptides having the (R-X-R)n motif are among the most effective cell-penetrating peptides (CPPs). Here, we report a several-fold increase in the efficacy of such CPPs if the linear flexible spacer (-X-) in the (R-X-R) motif is replaced by constrained cyclic 1,4-substituted-cyclohexane-derived spacers. Internalization of these oligomers in mammalian cell lines was found to be an energy-dependent process. Incorporation of these constrained, non-proteinogenic amino acid spacers in the CPPs was shown to enhance their proteolytic stability.

The article 《(R-X-R)4-motif peptides containing conformationally constrained cyclohexane-derived spacers: Effect on cellular uptake》 also mentions many details about this compound(3685-23-2)COA of Formula: C7H13NO2, you can pay attention to it, because details determine success or failure

Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate