A common heterocyclic compound, 538-58-9,1,5-Diphenylpenta-1,4-dien-3-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route. 538-58-9
General procedure: A flask equipped a magnetic stirring bar was charged with alpha,beta-unsaturatedketone 1 (1.0 mmol), tosylhydrazine(1.1 mmol), K2CO3 (1.5 mmol),and dioxane (2 ml). The reaction mixture was stirredunder a nitrogen atmosphere at 110 Cfor 24 h. The reaction mixture was cooled to room temperature; the reaction mixture was extracted with diethylether (5¡Á3 ml). The combined extracts was washed withbrine and dried over MgSO4, and the crude product was adsorbed ontosilica gel and purified by column chromatography (silica gel, petroleum ether:ethyl acetate 20:1) gave the pure saturated carbonyl compound 4.
This compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,538-58-9,1,5-Diphenylpenta-1,4-dien-3-one,its application will become more common.
Reference£º
Article; Zhou, Xiaomeng; Li, Xiaokang; Zhang, Wei; Chen, Junmin; Tetrahedron Letters; vol. 55; 37; (2014); p. 5137 – 5140;,
Synthesis and Crystal Structure of a Chiral?C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis
Chiral lanthanide(III) complexes of sulphur¨Cnitrogen¨Coxygen ligand derived from aminothiourea and sodium?D-camphor-¦Â-sulfonate