Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Methyl-1H-pyrrole, is researched, Molecular C5H7N, CAS is 616-43-3, about Synthesis and characterization of N-Mannich bases with pyrimethamine for antimicrobial activities.Computed Properties of C5H7N.
Schiff bases of isatin with pyrimethamine and its N-Mannich bases were synthesized. Antimicrobial evaluation was done by agar dilution method against 10 pathogenic bacteria and 4 pathogenic fungi. The new derivatives exhibited higher potency compared to the standard drugs against all organisms (against all bacteria). All the compounds exhibited antifungal activity.
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Reference:
Synthesis and Crystal Structure of a Chiral C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis,
Chiral lanthanide(III) complexes of sulphur–nitrogen–oxygen ligand derived from aminothiourea and sodium D-camphor-β-sulfonate