Day: August 20, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.538-58-9,1,5-Diphenylpenta-1,4-dien-3-one,as a common compound, the synthetic route is as follows.

General procedure: To a solution of DVK 1 (0.2 mmol) and active methylene 2 (0.24 mmol) was addedt-Bu-P2 (10uL, 10 mol%) via a micro syringe at room temperature. The reactionmixture was stirred for 2-24 h as indicated in Table 2. The solvent was then removedin vacuo and the crude product was purified by flash chromatography on silica gel(PE/EA = 15:1-10:1) to give the desired product 3.

As the paragraph descriping shows that 538-58-9 is playing an increasingly important role.

Reference£º
Article; Li, Yang-Guo; Zhang, Yang; Du, Guang-Fen; Gu, Cheng-Zhi; He, Lin; Letters in Organic Chemistry; vol. 16; 1; (2019); p. 76 – 80;,
Synthesis and Crystal Structure of a Chiral?C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis
Chiral lanthanide(III) complexes of sulphur¨Cnitrogen¨Coxygen ligand derived from aminothiourea and sodium?D-camphor-¦Â-sulfonate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.538-58-9,1,5-Diphenylpenta-1,4-dien-3-one,as a common compound, the synthetic route is as follows.

General procedure: A Schlenk tube with a magnetic stir bar charged with alpha,beta-unsaturated carbonyl compounds (0.5 mmol, 1 equiv), tosyl hydrazide (0.6 mmol, 1.2 equiv), NaOH (1.5 equiv), (n-Bu)4NBr (1.5 equiv). The reaction vessel was placed in an 80 C oil bath, and then stirring at this temperature for 10 h. The reaction mixture was then allowed to cool to ambient temperature, and diluted with 20 mL of ethyl acetate, and washed with brine (15 mL), water (15 mL), and then the organic layer was dried over Na2SO4. After concentrated in vacuo, the crude product was purified by column chromatography. The identity and purity of the known product was confirmed by 1H NMR, 13C NMR, and GC-MS.

The synthetic route of 538-58-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wen, Jun; Fu, Yun; Zhang, Ruo-Yi; Zhang, Ji; Chen, Shan-Yong; Yu, Xiao-Qi; Tetrahedron; vol. 67; 49; (2011); p. 9618 – 9621;,
Synthesis and Crystal Structure of a Chiral?C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis
Chiral lanthanide(III) complexes of sulphur¨Cnitrogen¨Coxygen ligand derived from aminothiourea and sodium?D-camphor-¦Â-sulfonate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24621-61-2,(S)-Butane-1,3-diol,as a common compound, the synthetic route is as follows.

(S)-(+)-Butane-1 ,3-diol (3.00 mmol, 0.270 g) was added to a stirred solution of imidazole (5.99 mmol, 0.41 g) and tert-butyldimethylsilyl chloride (3.00 mmol, 0.45 g) at room temperature. After six hours at room temperature water (50 mL) was added and extracted twice with dichloromethane (20 mL). The combined organic extracts were washed with brine, dried (sodium sulfate) and concentrated in vacuo to yield (S)-4- (tert-butyldimethylsilyloxy)butan-2-ol (0.654 g).

As the paragraph descriping shows that 24621-61-2 is playing an increasingly important role.

Reference£º
Patent; N.V. ORGANON; MAN de,, Adrianus Petrus Antonius; REWINKEL,, Johannes Bernardus Maria; JANS,, Christiaan Gerardus Johannes Maria; RAAIJMAKERS,, Hans Cornelis Andreas; WIJKMANS,, Jacobus Cornelis Henricus Maria; WO2011/95556; (2011); A1;,
Synthesis and Crystal Structure of a Chiral?C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis
Chiral lanthanide(III) complexes of sulphur¨Cnitrogen¨Coxygen ligand derived from aminothiourea and sodium?D-camphor-¦Â-sulfonate

538-58-9, 1,5-Diphenylpenta-1,4-dien-3-one is a chiral-oxygen-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

.) Synthesis According to Inorganic Synthesis, 28, 110 (1990)The synthesis is carried out under inert gas. 2.096 g (11.73 mmol) PdCl2 and 0.686 g (11.73 mmol) NaCl are provided under argon, and 59 ml of methanol are added.Next the reaction mixtures is stirred over night for 18 hours in the sealed flask. Then the dark red-brown solution is filtered through a G3 frit under argon. No residue is evident on the frit.The filtrate solution is transferred to a 500 ml three-necked flask using 293 ml of methanol, and heated to 60 C. At this temperature, 8.563 g (36.54 mmol) dibenzylidene acetone are added under argon. Then, the addition of 17.595 g (214.49 mmol) sodium acetate is made.A voluminous, reddish solid precipitates. Subsequently, the reaction mixture is cooled to room temperature. The product is removed by filtration and washed with 300 ml of methanol, 300 ml of water, and 300 ml of acetone. The product is dried in vacuo at room temperature.Appearance: dark-brown solidSolubility Test:1.00 g of the product are dissolved in 150 ml of chloroform and stirred at room temperature for 30 minutes. The solution is then aspirated through a membrane filter. The filter is washed with 30 ml of water and 30 ml of acetone and subsequently dried over night at 45 C. in vacuo. The residue accounts for 1.4%.Result:m(product): 6.4 gYield with respect to Pd: 94CHCl3-insoluble ingredients: 1.4

The synthetic route of 538-58-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; W.C. Heraeus GmbH; US7999126; (2011); B2;,
Synthesis and Crystal Structure of a Chiral?C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis
Chiral lanthanide(III) complexes of sulphur¨Cnitrogen¨Coxygen ligand derived from aminothiourea and sodium?D-camphor-¦Â-sulfonate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.538-58-9,1,5-Diphenylpenta-1,4-dien-3-one,as a common compound, the synthetic route is as follows.

Bis(dibenzylideneacetone)palladium(0) (Pd(dba)2)was synthesized by reducing PdCl2 with methanol in thepresence of sodium acetate and dba [30]. Dibenzylideneacetone(3.4500 g, 1.472 ¡Á 10-2 mol), sodium acetatetrihydrate (4.8525 g, 3.568 ¡Á 10-2 mol), and methanol(113 mL) were placed in a two-neck round-bottomflask. The reaction mixture was stirred at 50C for 45-60 min to obtain a solution, and PdCl2 (0.7875 g,4.434 ¡Á 10-3 mol) was added. The resulting solutionwas stirred in an argon atmosphere at 40C for 4 h.This yielded a dark violet precipitate of the Pd(dba)2complex, which was collected on a fritted glass filterunder argon, washed with water and acetone, andvacuum-dried (30C/2-3 Torr) for 3 h. The productyield was 2.4 g. (94% of the theoretical yield); m =152C. According to the literature, m of thePd(dba)2 complex is 152C [31]. UV spectra:Pd(dba)2, 525 nm (d ? d* transition, epsilon525 =6400 L mol-1 cm-1); non-coordinated dba, 325 nm(n ? pi* transition, epsilon325 = 33540 L mol-1 cm-1).

538-58-9 1,5-Diphenylpenta-1,4-dien-3-one 95417, achiral-oxygen-ligands compound, is more and more widely used in various.

Reference£º
Article; Skripov; Belykh; Sterenchuk; Akimov; Tauson; Schmidt; Kinetics and Catalysis; vol. 58; 1; (2017); p. 34 – 45; Kinet. Katal.; vol. 58; 1; (2017); p. 36 – 48,13;,
Synthesis and Crystal Structure of a Chiral?C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis
Chiral lanthanide(III) complexes of sulphur¨Cnitrogen¨Coxygen ligand derived from aminothiourea and sodium?D-camphor-¦Â-sulfonate

4254-15-3, (S)-Propane-1,2-diol is a chiral-oxygen-ligands compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(1) Feeding800 kg of S-propylene glycol, 1600 kg of dimethyl carbonate and 8 kg of sodium methoxide solution were added to the reaction vessel, and heating and stirring were started.The sodium methoxide solution is a 30percent sodium methoxide/methanol solution;The S-propanediol has a propylene glycol content of 99.5percent, a moisture content of 0.5percent, and a specific rotation of ?16.80-17. (2) Temperature rise reactionFirst stage heating reaction The temperature is raised to 60-65 ¡ã C, at which time a solution (mainly methanol, a small portion of dimethyl carbonate) is distilled off, received in the receiving tank, and the solution is evaporated; Second stage heating reactionThereafter, after about 12 hours, the temperature is raised from 65 ¡ã C to 90 ¡ã C, the solution is kept distilled, and the product is distilled as a by-product alcohol-based fuel (methanol and dimethyl carbonate); Third stage temperature rise reactionHeating was continued, and the temperature was raised from 90 ¡ã C to 115 ¡ã C for 8 hours, and the heating was stopped. (3) Cooling downThe temperature was lowered from 115 ¡ã C to 60 ¡ã C. The temperature in the reaction vessel is ?90 ¡ã C, and the alcohol-based fuel (mixed solution of methanol and dimethyl carbonate) is distilled off; most of the steam distilled out at >90 ¡ã C is dimethyl carbonate, and a small amount of methanol is used as a reaction raw material for recovery. (4) Decompression reaction under reduced pressureStart decompression under reduced pressure, using vacuum distillation, vacuum degree ? -0.08mpa, the temperature rises at a rate of 0.2 ¡ã C per minute,Continue to distill the solution (a mixture of methanol and dimethyl carbonate),Keep the solution evaporated, when the temperature rises to 120 ¡ã C, basically no solvent comes out at this time,The pressure reduction and desolvation can be stopped, and the temperature is lowered; the remaining liquid in the reaction tank is (S)-propylene carbonate. In the crude (S)-propylene carbonate, the (S)-propylene carbonate content is 97percent or more. From the start of the preparation to the preparation of the crude product, the reaction time was 25 hours. (5) Distillation reactionTransfer the remaining liquid after decompression and decompression to the rectification bottle, and turn on the heating and stirring.Vacuuming, ensuring a vacuum degree ? 0.1Mpa, starting the steaming before the fraction, steaming out about 100kg of the former fraction, and then transferring the finished product.The materials in the rectification tank were all distilled off, the rectification was stopped, and (S)-propylene carbonate was collected. The (S)-propylene carbonate has the following quality indicators:1. Appearance: colorless clear liquid;2, SPC chemical purity content (percent): ? 99.8;3, SPC optical purity content (percent): ? 99.4;4. SPC isomer content (percent): ? 0.6;5. Moisture (percent): ? 0.1; The yield of the finished SPC is 97percent; the specific rotation is -2 to -3;

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Reference£º
Patent; Weifang Huitao Chemical Co., Ltd.; Liu Jianwei; Zhang Quansheng; Wei Lanxing; Hua Xian; (6 pag.)CN109369401; (2019); A;,
Synthesis and Crystal Structure of a Chiral?C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis
Chiral lanthanide(III) complexes of sulphur¨Cnitrogen¨Coxygen ligand derived from aminothiourea and sodium?D-camphor-¦Â-sulfonate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24621-61-2,(S)-Butane-1,3-diol,as a common compound, the synthetic route is as follows.

Production of (S)-3-Hydroxy-1-(p-toluenesulfonyloxy)butane In the same manner as in the first step of Production Example 32, the desired compound (77.5 g) was obtained as light brown oil from (S)-1,3-butanediol (30.0 g) and p-toluenesulfonyl chloride (69.8 g). The thus-obtained oil was immediately subjected to the next step.

24621-61-2 (S)-Butane-1,3-diol 446973, achiral-oxygen-ligands compound, is more and more widely used in various.

Reference£º
Patent; Fujisawa Pharmaceutical Co., Ltd.; US6420409; (2002); B1;,
Synthesis and Crystal Structure of a Chiral?C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis
Chiral lanthanide(III) complexes of sulphur¨Cnitrogen¨Coxygen ligand derived from aminothiourea and sodium?D-camphor-¦Â-sulfonate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.538-58-9,1,5-Diphenylpenta-1,4-dien-3-one,as a common compound, the synthetic route is as follows.

General procedure: To a solution of dialkyl phosphite (0.01 mol) in anhydrous tetrahydrofuran (30 mL),maintained under a nitrogen atmosphere, sodium (0.02 g) was added and the mixture was stirred at roomtemperature until complete dissolution of sodium. Diarylideneketone 1 (0.01 mol) was then added and themixture heated under reflux for 4 h. After cooling, the reaction mixture was diluted with water (50 mL)and extracted with CHCl3 (2 ¡Á 25 mL). The organic phase was dried over Na2SO4 and concentrated undervacuum. The obtained residue was chromatographed on a silica gel column using a mixture of Et2O andhexane 9:1 as an eluent.

538-58-9 1,5-Diphenylpenta-1,4-dien-3-one 95417, achiral-oxygen-ligands compound, is more and more widely used in various.

Reference£º
Article; Lamouchi, Imen; Touil, Soufiane; Heterocycles; vol. 94; 5; (2017); p. 894 – 911;,
Synthesis and Crystal Structure of a Chiral?C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis
Chiral lanthanide(III) complexes of sulphur¨Cnitrogen¨Coxygen ligand derived from aminothiourea and sodium?D-camphor-¦Â-sulfonate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4254-15-3,(S)-Propane-1,2-diol,as a common compound, the synthetic route is as follows.

To a stirred solution of (A)-propane-l,2-diol (5 g, 65.7 mmol) in anhydrous DCM (40 mL) at 0 C, was added imidazole (4.47 g, 65.7 mmol), followed by TBDMS-C1 (10.89 g, 72.3 mmol). After being stirred at room temperature for 4 h, the reaction mixture was cooled to 0C, and partitioned between sodium bicarbonate solution (50 ml) and DCM (200 mL). The organic layer was washed with EhO, and saturated NaCl solution, dried over anhydrous Na2S04, filtered and concentrated under reduced pressure fV)- l -((/tW-butyl dimethyl si lyl)oxy)propan-2-ol ^2 g, 63.0 mmol, 96% ) as colourless oil. NMR (400 MHz, chloroform-^ d ppm 3.73 – 3.88 (m, 1H), 3.51 – 3.65 (m, 1H), 3.29 – 3.46 (m, 1H), 2.36 – 2.56 (m, 1H), 1.12 (d, J=6.53 Hz, 3H), 0.90 – 0.96 (m, 9H), 0.06 – 0.13 (m, 6H).

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Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; BALOG, James Aaron; SEITZ, Steven P.; WILLIAMS, David K.; ANDAPPAN MURUGAIAH SUBBAIAH, Murugaiah; (191 pag.)WO2019/136112; (2019); A1;,
Synthesis and Crystal Structure of a Chiral?C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis
Chiral lanthanide(III) complexes of sulphur¨Cnitrogen¨Coxygen ligand derived from aminothiourea and sodium?D-camphor-¦Â-sulfonate

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4254-15-3,(S)-Propane-1,2-diol,as a common compound, the synthetic route is as follows.

To a stirred solution of 68 (S)-2-propanediol (1.00g, 13.14mmol) in 14 dichloromethane/69 pyridine (10:10 V/V) at -25C under argon was added dropwise 70 p-toluenesulfonyl chloride (2.51g, 13.14mmol) dissolved in 10mL of CH2Cl2 over a period of 2h. The mixture was stirred at -25C for 4h and then at room temperature for further 2h. After the reaction was completed, 30mL of CH2Cl2 were added and the mixture was shaken successively with ice-cold water, 1M 10mL 71 aqueous HCl, 15mL 72 water, saturated NaHCO3, and water, respectively. The organic phase was dried over MgSO4 and filtered and the solvent was removed under reduced pressure. The residue was purified by chromatography over silica gel using toluene/EtOAc (5/1) to give 73 product (1.70g, 56%) as white crystals. M.p: 33-35C, [alpha]D25=-12.05 (c 1, CHCl3). 1H NMR (CDCI3, ppm): delta 7.80 (d, 2H, J=8.0Hz, of OTs), 7.36 (d, 2H, J=8.0Hz, of OTs), 3.97-4.05 (m, 2H, -CHCH3-+CH2OTs (a)), 3.83-3.88 (m, 1H, CH2OTs (b)), 2.45 (s, 3H, -CH3 of OTs), 2.39 (s, 1H, OH), 1.15 (d, J=6.4Hz, 3H, -CHCH3), assignment was based on the 1H-13C HETCOR and 1H-1H COSY spectra

The synthetic route of 4254-15-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Meric, Nermin; Kayan, Cezmi; Guerbuez, Nevin; Karakaplan, Mehmet; Binbay, Nil Ertekin; Aydemir, Murat; Tetrahedron Asymmetry; vol. 28; 12; (2017); p. 1739 – 1749;,
Synthesis and Crystal Structure of a Chiral?C3-Symmetric Oxygen Tripodal Ligand and Its Applications to Asymmetric Catalysis
Chiral lanthanide(III) complexes of sulphur¨Cnitrogen¨Coxygen ligand derived from aminothiourea and sodium?D-camphor-¦Â-sulfonate